Wpływ muzyki relaksacyjnej na zdrowie pacjenta w oparciu o elementy muzyki klasycznej podczas operacji kardiochirurgicznych (PDF 2,18 MB)

Abstract

Music plays a specific role in the life of every person, from a young
infant to an adult. Although it is interpreted as a very individual and
subjective feeling, numerous studies have shown that objective parameters such as heart rate, secretion of happiness hormones: serotonin
and endorphins, lower blood pressure and other physiological parameters are more pronounced when listening to a specific type of music. That is why it has been used in many medical disciplines, including
non-invasive cardiac surgery, cardiology, orthopaedics, gynaecology,
visceral surgery and neurodegenerative diseases such as Parkinson’s
or Alzheimer’s, and in the area of intensive care. The oxidative stress
felt by all of us, expressed in pain, fear and anxiety, can be effectively
relieved by relaxing music. It also protects against DNA destabilisation in living organisms by molecular oxygen in tissues, which can
cause damage to various parts of cells, such as platelets, mitochondrial membranes, which can be one of the factors in the development
of neurodegenerative diseases and disorders in thrombosis. These
diseases arise due to intermediate oxygen molecules, such as lipid
peroxidation processes (fat oxidation). These molecules can oxidise
DNA bases in mitochondrial DNA (mtDNA) to reactive compounds,
such as methylated or oxidised base pairs, to exocyclic ethanol and
propane adducts, which can be a risk factor for the development of
various pathologies, including cancers. Both platelet, mitochondrial
membrane and solid tissue dysfunction processes can cause disorders
in thrombosis through a different DNA repair mechanism, which affects premature neoplastic changes in critical suppressor genes such
as the p53 gene. These changes can lead to various types of cancer
through the stage of DNA base modification. Understanding the
genotoxic properties of endogenous DNA damage as ethenodene
adducts such as 1,N6-ethenoadenine (etA), 3,N4-ethenocytosine
(etC), N2,3-ethenoguanine (etG) and 1,N2-ethenoguanine (etG)
and repair pathways is fundamental for understanding the mechanisms of diseases that depend on chronic inflammation, such as
cancer or neurodegenerative diseases, and aging processes. Due to
the wide range of these products and pleiotropic effects, knowledge
about the molecular mechanisms of thrombosis is still fragmentary. Music therapy as a field of science, coupled with medicine and
its branches, plays an important role in patients with severe symptoms of depression, schizophrenia, bipolar disorder, delirium and or
emergency surgical interventions. Literature data indicate the positive influence of music and its various types observed in many difficult medical cases where only palliative treatment was possible.
Understanding various physiological and pathophysiological impulses in the brain continues to be an active area of research. The greatest health benefits are found in pop, rock, relaxation music and especially in classical music: the compositions of Bach, Mozart, Tchaikovsky,
Schubert and Wagner, as well as Italian composers.